Juniper Publishers-International Journal of Pulmonary & Respiratory Sciences

  Abstract Background: Tuberculosis (TB) is a grave infectious disease caused by the bacillus Mycobacterium tuberculosis (MTB). Pulmonary tuberculosis remains an important public health problem globally and one of most common infectious disease. Tuberculosis can cause wide variety of complication respiratory or non-respiratory. We studied complication and sequelae of pulmonary tuberculosis. Methodology: A prospective observational study was conducted, the study included all patients presenting with complications of tuberculosis in newly diagnosed and previously treated patients referred to the Pulmonary Medicine Department. Patients not willing to give consent for the study or the patient with incomplete data were excluded. TB was diagnosed on the basis of sputum Gene Expert, Line Probe Assay and Conventional Drug Sensitivity testing. Results: Of the total 310 cases, 176(57%) patients were males and 134(43%) were female patients. The mean age of all patient...

  Abstract Background:   Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases. To date, most drug trials for the treatment of IPF have yielded disappointing results. Recently, selenium nano-particles (SeNP) have received attention for potential use in treatments, due in part to their established abilities to exert size-dependent anti-oxidant/-inflammatory effects. Materials and Methods:   the rats were treated with SeNPs by intraperitoneal injection (0.5mg SeNP/kg) for five consecutive days in the inflammatory phase (a day after injection of bleomycin) and fibrotic phase (a week after injection of bleomycin). Results:   The results showed that administration of SeNP during the inflammatory phase improved the activity of enzymes antioxidant (i.e., glutathione peroxidase and superoxide dismutase) and also led to significant decreases in interleukin (IL)-6 and malondialdehyde (MDA) levels in lung homogenates. Histopathology, measures of lung inde...

  Abstract In order to mitigate the spread of the COVID-19 infection in India, the Indian government granted approval for the emergency use of Oxford-AstraZeneca’s COVID-19 (coronavirus disease 2019) vaccine AZD1222 (Covishield). The biggest large-scale COVID-19 vaccination drive in the world is being carried out continuously till date in India. In this research article, a possible cluster of AEFI (Adverse Event Following Vaccination) following AZD1222 (Covishield) vaccination in India has been briefly presented. Read more about this article: https://juniperpublishers.com/ijoprs/IJOPRS.MS.ID.555676.php Read more Juniper Publishers Google Scholar Articles: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=Y8LS2LwAAAAJ&citation_for_view=Y8LS2LwAAAAJ:70eg2SAEIzsC  

  Abstract Objective: Diabetic feet and toe deformities is commonly associated with diabetes mellitus and neuropathy is the causative factor combined with vasculopathy. In this study we list out various morphological changes which occur in Diabetic foot lesions, the pathophysiology and the management of the deformed toes and feet. Materials and Methods: A prospective study was carried out in patients presenting to the Diabetic Clinic at a tertiary care hospital in Delhi. 70 patients who were labelled as diabetics formed the study group. Results: The most common age group affected belonged to 51-60 age bracket which included 41 patients (58.5%). The male to female ratio was approximately 3:1. Majority of patients 32 (45.71%) had diabetes of >10 years duration. Foot and toe deformities affected majorly diabetics with moderately controlled diabetes mellitus and the study revealed that 40 patients (57.2%) had moderately controlled diabetes with blood sugar lev...

  Abstract Background: Brain Natriuretic Peptide (BNP) levels increase in response to exercise in congestive heart failure patients. However, the timing, degree, and clinical consequences of exercise-related BNP elevation in Pulmonary Arterial Hypertension (PAH) remain unexplored. Materials and methods: A total of 38 consecutive PAH patients were enrolled in this study. BNP levels were drawn prior to, and 6, 14, 20, and 60 minutes following, the six-minute walk test. Subjects were divided based on BNP level cut off used in our laboratory: BNP ≤100pg/ml and BNP >100pg/ml. Time to Clinical Worsening (TTCW) was defined as a composite end point of death, transplant, prostacyclin initiation, or hospitalization for worsening PAH. Results: Twenty-four patients were in the BNP ≤100pg/ml group (44±28pg/ml, mean ± SD) and fourteen patients in the BNP >100pg/ml group (285±179pg/ml). Baseline six-minute walk distance in the ≤100pg/ml group was higher as compar...

  Abstract Nucleic acid based-mRNA based and adenovirus vectored-vaccines, were first ever or first commercially ever approved for the public, respectively. However, these newly emergency approved types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia, myocarditis and immune induced thrombosis and thromboembolism that might be fatal and could reason for some of the post vaccination sudden death reports. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients as well as they might share in development of som...