Effects of Selenium Nanoparticles on Bleomycin-Induced Pulmonary Fibrosis in Rats

 

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases. To date, most drug trials for the treatment of IPF have yielded disappointing results. Recently, selenium nano-particles (SeNP) have received attention for potential use in treatments, due in part to their established abilities to exert size-dependent anti-oxidant/-inflammatory effects.

Materials and Methods: the rats were treated with SeNPs by intraperitoneal injection (0.5mg SeNP/kg) for five consecutive days in the inflammatory phase (a day after injection of bleomycin) and fibrotic phase (a week after injection of bleomycin).

Results: The results showed that administration of SeNP during the inflammatory phase improved the activity of enzymes antioxidant (i.e., glutathione peroxidase and superoxide dismutase) and also led to significant decreases in interleukin (IL)-6 and malondialdehyde (MDA) levels in lung homogenates. Histopathology, measures of lung index and body weight, and evaluations of lungs using Ashcroft criteria supported the mitigative effects found above. Notably, treatment with the SeNP during the fibrotic phase imparted no ameliorative effects. Lastly, the SeNP themselves seemed to impart no overt toxicities in naïve rat hosts.

Conclusion: Thus, the findings suggest that SeNP, in part by improving the antioxidant enzyme activities, might impart a therapeutic effect against PF induced by bleomycin in rats. This potentially might mean that SeNP could represent a new therapeutic for treatment of this disease, at least in its earliest phases. 

Read more about this article: https://juniperpublishers.com/ijoprs/IJOPRS.MS.ID.555675.php

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