Juniper Publishers-International Journal of Pulmonary & Respiratory Sciences

  Abstract Background:   Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases. To date, most drug trials for the treatment of IPF have yielded disappointing results. Recently, selenium nano-particles (SeNP) have received attention for potential use in treatments, due in part to their established abilities to exert size-dependent anti-oxidant/-inflammatory effects. Materials and Methods:   the rats were treated with SeNPs by intraperitoneal injection (0.5mg SeNP/kg) for five consecutive days in the inflammatory phase (a day after injection of bleomycin) and fibrotic phase (a week after injection of bleomycin). Results:   The results showed that administration of SeNP during the inflammatory phase improved the activity of enzymes antioxidant (i.e., glutathione peroxidase and superoxide dismutase) and also led to significant decreases in interleukin (IL)-6 and malondialdehyde (MDA) levels in lung homogenates. Histopathology, measures of lung inde...

  Abstract In order to mitigate the spread of the COVID-19 infection in India, the Indian government granted approval for the emergency use of Oxford-AstraZeneca’s COVID-19 (coronavirus disease 2019) vaccine AZD1222 (Covishield). The biggest large-scale COVID-19 vaccination drive in the world is being carried out continuously till date in India. In this research article, a possible cluster of AEFI (Adverse Event Following Vaccination) following AZD1222 (Covishield) vaccination in India has been briefly presented. Read more about this article: https://juniperpublishers.com/ijoprs/IJOPRS.MS.ID.555676.php Read more Juniper Publishers Google Scholar Articles: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=Y8LS2LwAAAAJ&citation_for_view=Y8LS2LwAAAAJ:70eg2SAEIzsC  

  Abstract Nucleic acid based-mRNA based and adenovirus vectored-vaccines, were first ever or first commercially ever approved for the public, respectively. However, these newly emergency approved types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia, myocarditis and immune induced thrombosis and thromboembolism that might be fatal and could reason for some of the post vaccination sudden death reports. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients as well as they might share in development of som...