Juniper Publishers-International Journal of Pulmonary & Respiratory Sciences

  Abstract Background:   Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases. To date, most drug trials for the treatment of IPF have yielded disappointing results. Recently, selenium nano-particles (SeNP) have received attention for potential use in treatments, due in part to their established abilities to exert size-dependent anti-oxidant/-inflammatory effects. Materials and Methods:   the rats were treated with SeNPs by intraperitoneal injection (0.5mg SeNP/kg) for five consecutive days in the inflammatory phase (a day after injection of bleomycin) and fibrotic phase (a week after injection of bleomycin). Results:   The results showed that administration of SeNP during the inflammatory phase improved the activity of enzymes antioxidant (i.e., glutathione peroxidase and superoxide dismutase) and also led to significant decreases in interleukin (IL)-6 and malondialdehyde (MDA) levels in lung homogenates. Histopathology, measures of lung inde...

  Abstract Nucleic acid based-mRNA based and adenovirus vectored-vaccines, were first ever or first commercially ever approved for the public, respectively. However, these newly emergency approved types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia, myocarditis and immune induced thrombosis and thromboembolism that might be fatal and could reason for some of the post vaccination sudden death reports. Moreover, all SARS CoV-2 types of vaccines, depending on the spike protein immunogenicity, especially the conventional inactivated ones might increase the likelihood of COVID-19 severity upon re-infection through antibody dependent enhancement which might reason for the recently described abundance of hospital admissions within seven days of vaccination and might also reason for some of the serious adverse effects encountered with administration of convalescent plasma to COVID-19 patients as well as they might share in development of som...

  Introduction Modern ideas about the nature of acute pneumonia (АР) are the main obstacle to its successful treatment. On the one hand, AP is not considered a contagious infectious disease, does not require isolation of patients and the observance of special precautions, and the known and widespread today pathogens of AP belong to representatives of symbiotic microflora of healthy people. On the other hand, all hopes for the successful treatment of the disease are pinned only on antimicrobial effects. “Antibiotics alone” is the initial treatment of all patients with AP. The emergence of more and more antibiotic resistant strains of microorganisms is a natural consequence of long-term and intensive use of such treatment. Adaptability of microorganisms as representatives of the biological world is their essential feature. The ongoing process of confrontation between the natural presence of microbes in many areas of our body and the means of its suppression is ...

  Opinion All that is shortness of breath is not pulmonary. We have identified a cohort of 18 outpatients in a general otolaryngology practice in New York City who presented with persistent shortness of breath (SOB) despite normal pulmonary imaging. All patients had cough, fever and SOB between March 15 - May 15, 2020 during the height of the COVID-19 pandemic in New York City, with the SOB persisting for 4 - 12 weeks at the time of their presentation. 3/12 were positive for COVID-19 IgG antibodies, one of whom also tested positive with a nasal swab polymerase chain reaction (PCR) assay. Due to limited access, only 12 patients were able to obtain an antibody test and only 7 were able to get the PCR test. Of the 4 patients who had spirometry as part of their pulmonary investigation, the flow volume loop showed flattening of the inspiratory curve in all 4. History revealed that the SOB was generally not waking these patients up at night nor was it affecting their e...